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The latter showed therefore significative trace metal release, up to 2 kg ha-1 year-1 for zinc, doubling the local atmospheric Synthesis and reactions of phosphaporphyrins: reconstruction of pi-skeleton triggered by oxygenation of a core phosphorus atom.University, Nishikyo-ku, Kyoto 615-8510, Japan.The synthesis, structures, optical and redox properties, and reactivity of dehydrative condensation between a phosphatripyrrane and the corresponding 2,5-bis[hydroxy(phenyl)methyl]heteroles followed by 2,3-dichloro-5,6-dicyanobenzoquinone oxidation. Experimental (NMR, UV-vis, and X-ray analyses) and theoretical (DFT calculations) results suggest that the 18pi phosphaporphyrins. X-ray crystallography revealed a slightly distorted 18pi rings tilted from the 24-atoms mean plane by 9 degrees and 3-15 degrees, respectively. DFT calculations on model compounds showed that the absorptions, low oxidation potentials, and high reduction potentials of the has been found to lead to the formation of different types of products.<br /><br /> The 18pi subsequently transformed into the 22pi or 20pi porphyrins. The two reaction courses from 18pi to 20pi/22pi are apparently determined by the combination of peripherally fused carbocycles. The present results demonstrate that the incorporation of a phosphorus atom into the core is not only a highly promising way to modify the fundamental properties of the porphyrin 18pi system but also a reliable tool to stabilize uncommon 22pi and 20pi systems through the chemical modifications at the core phosphorus atom.N-terminal tyrosine residue are agonists at the mu-opioid receptor.shown previously to exhibit high affinity and selectivity for the mu-opioid affinity of this peptide, 11 analogs of JH-54 have been synthesized and evaluated for opioid ligand binding and for efficacy using the [(35)S]GTPgammaS residues of JH-54 from dithioether to disulfide revealed the importance of the relative position of the aromatic rings of the first and third residues in determining mu- and delta-affinities. The one carbon distance between the alpha carbon and phenyl ring in the N-terminal residue was critical. Additional steric in affinity in two naphthyl analogs, but not with 3, 3-(diphenyl)alanine.<br /><br /> Conformational restriction of the Calpha-Cbeta and/or Cbeta-Cgamma bonds had little effect on affinities in two peptides with 2-amino-2-carboxytetralin in position 1, but it abolished activity in an isoquinoline analog and resulted in a peptide of moderate affinity (K(i) = 32 nM) and potency (EC(50) = 58 nM). Thus, the tyrosyl para-hydroxyl substituent and even aromaticity in the N-terminal amino acid of these tetrapeptides are shown to be important, but not critical, features for mu-opioid receptor affinity, agonist potency, and Direct Synthesis of ABCD-Porphyrin Platinum(II) Complexes via Dehydrative Environmental Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Since the development of the first method for porphyrin synthesis by Rothemund in 1935, porphyrin derivatives have been widely investigated and have played an essential role in chemical sciences. Most synthetic routes of porphyrins involve oxidative aromatization. Herein, we present a synthetic method to produce ABCD-porphyrins, including chiral ones, through a one-pot reaction involving "coordination, cyclization, and dehydrative aromatization" using a mono-dipyrrinatoPt(II)Cl(COE) (COE=cyclooctene) complex as a platinum template.Design and manufacture of an all-polymeric integrated multimode interferometer Gordo FJ, Tátá J, Borme J, Geday MA, Caño-García M, Nieder JB.This work demonstrates an integrated multimode interferometer (MMI) based on a fully polymeric platform and optimized for visible range operation. The dimensions of a 2×2 MMI are first calculated analytically and simulated using finite elements method.<br /><br /> The devices are manufactured using two layers of negative tone photoresists. [http://allinno.com/news/166.html Photosensitive Acid Generator] is patterned by e-beam lithography demonstrating the adaptability of this material, naturally designed to respond to UV radiation. [http://en.wikipedia.org/wiki/Photoacid Seebio Photoacid Generator] was smaller than 100 nm. [http://en.wikipedia.org/wiki/Photoresist Learn more] were optically characterized with a 635 nm input source and the best performance for a 3 dB power splitter was found at an interferometric cavity dimension of 10 × 1908 µm. Other interferometric lengths were characterized to establish a process design kit that allows future use of this platform in more complex photonic integrated circuits architectures.Diels-Alder reaction-aromatization approach toward functionalized ring C allocolchicinoids. Enantioselective total synthesis of (-)-7S-allocolchicine.<br /><br />Allocolchicinoids are analogues of the important antimitotic compound (-)-colchicine 1. A strategy is reported for the synthesis of ring C functionalized allocolchicinoids, which is based on a Diels-Alder reaction-aromatization sequence. This route is complementary to the previously disclosed benzannulation approach involving Fischer carbene complexes and alkynes.