-GSH-levels-in-seminal-plasma-do-not-correlate-with-ET-levels-k

This suggests that the function of ET, at least in this extracellular context, does This paper reviews the structure, function and applications of collagens as biomaterials. The various formats for collagens, either as tissue-based devices or as reconstituted soluble collagens are discussed. The major emphasis is on the new technologies that are emerging that will lead to new and improved collagen-based medical devices. In particular, the development of recombinant collagens, especially using microorganism systems, is allowing the development of safe and reproducible collagen products. These systems also allow for the development of novel, non-natural structures, for example collagen like structures containing repeats of key functional domains or as chimeric structures where a collagen domain is covalently linked to another biologically [Effects of different types of collagen on the aggregation and proliferation of bovine articular chondrocytes cultured in vitro].In the presence of different types of native collagens, particularly type III, isolated chondrocytes do not attach as usual to the plastic walls of culture flasks, but instead aggregate and form nodules and floating pellicules.

Furthermore, squalane grow differently in the absence or presence of collagen. In the presence of collagen they grow more rapidly and form nodules and large pellicules. Foetal calf and horse serum and bovine synovial fluid contain dialysable factor(s) that inhibit attachment of the cells to the culture walls, but enhance collagen-induced cell aggregation of the chondrocytes.Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly.BACKGROUND: An open, randomized, multicenter study was carried out in elderly to compare the immunogenicity and reactogenicity of a conventional influenza split vaccine (SpV) with an MF59-adjuvanted subunit vaccine (aSuV) and a virosome-based subunit vaccine (vSuV) since earlier studies reported better immunogenicity for adjuvanted and virosome-based vaccines.PATIENTS AND METHODS: A total of 840 subjects, aged 60 years or more, who had not been vaccinated or diagnosed with influenza in the preceding season were investigated. Hemagglutination-inhibition antibody titers were measured, and RESULTS: The three vaccines exceeded EU efficacy requirements for subjects aged older than 60 years and seroprotective levels (titers > 1:40) were equally maintained with the three vaccines during 8 months post vaccination.

SpV was as immunogenic as aSuV for the A/H3N2 strain (p < 0001) and significantly more immunogenic than aSuV for A/H1N1 strain (p = 0006). SpV was as immunogenic as vSuV for all three strains and significantly more immunogenic than vSuV for the A/H1N1 strain (p < 0001). In squalane cleanser of reactogenicity, aSuV showed a higher rate of solicited local signs and symptoms than SpV (p = 021) and vSuV (p = 046), respectively. Incidence of solicited general symptoms was comparable on all treatments. No serious adverse event related to vaccination was reported.CONCLUSION: These findings suggest that all three vaccines are highly immunogenic with an acceptable reactogenicity profile and that they are Acute effects of weight reduction on cholesterol metabolism in obese type 2 Helsinki, PO Box 340, 00029 HYKS Helsinki, Finland.BACKGROUND: Weight reduction in obese type 2 diabetes increases the absorption efficiency of cholesterol and serum plant sterol levels from baseline.

However, there is no information on the effects of acute restriction of calories and lack of dietary cholesterol and plant sterols on serum cholesterol precursor and type 2 diabetes subjects consumed very low energy diet virtually free of cholesterol, cholestanol and plant sterols for 3 months.METHODS: Serum sterols were measured with gas-liquid chromatography.RESULTS: Body weight was reduced by 15+/-1 kg (p<001), serum cholesterol by 21+/-3%, triglycerides 45+/-5%, glucose 23+/-3%, insulin 59+/-5% and HbAIc by 8+/-2%, whereas serum sex hormone binding globulin increased by 108+/-25% (p<05-001 for all). Serum desmosterol and lathosterol to cholesterol ratios (indicators of cholesterol synthesis) were significantly decreased by 20% suggesting that cholesterol synthesis was suppressed. Serum squalene ratio was unchanged. Despite lack of dietary plant sterols and cholestanol, serum campesterol and sitosterol ratios (indicators of cholesterol absorption efficiency) only tended to decrease, whereas serum cholestanol ratio, also an absorption indicator, was increased by 33+/-3% (p<001), and its ratios to campesterol and sitosterol were increased by 60% and 31%, suggesting that sterol absorption efficiency might have been increased and their turnover reduced.CONCLUSIONS: In obese type 2 diabetes, restriction of calories and dietary sterols improved markedly control of diabetes, decreased serum cholesterol precursor sterols suggesting that cholesterol synthesis was decreased, but only tended to decrease serum values of plant sterols probably due to their release from the adipose tissues associated with their impaired turnover.

Anticarcinogenic compounds of olive oil and related biomarkers.