The-conversion-rate-for-the-51-persons-who-were-negative-at-the-dilution-of-120-at-the-outset-was-94-b

Sixty-four of the 77 persons with an antibody of 1:20 or less volunteered to take the vaccine and were examined six weeks later for the development of antibodies. ; the rate of antibody increment for the 13 persons who were positive at 1:20 at the outset was 77%. Among the 51 persons who developed antibodies, the geometric mean titre was 1:57 and among the other 13 it was 1:49. Although the trial was conducted in adult females, the number of side effects from the vaccine was remarkably scanty and insignificant. This trial would seem to emphasize the importance of avoiding the use of rubella vaccine in women of child-bearing age without first excluding pregnancy with meticulous care and using active and controllable contraceptive methods for the two months following Immunogenicity study on the measles vaccines.storage conditions.

Polysucrose 400 Food additive are vital in promoting public health. Failures in immunization programmes often times are blamed on disruption in vaccine cold-chain. This study assessed the immunogenicity/potency of the measles vaccines utilized in childhood immunization in South-East, Nigeria and indirectly assessed the effectiveness of the cold-chain technology in the region. METHODS: This was an experimental study carried out between December 2011 and June 2013. Antibody induction method was used to evaluate the immunogenicity/potency of the measles vaccines sourced from the central cold chain facilities in South-east, Nigeria and indirectly, the effectiveness of the cold chain technology in the zone in maintaining vaccine potency. The neutralizing antibodies in a control group (administered with measles vaccines stored at 37°C for 12 months) and in immunized group were determined after 30 days of immunization using ELISA. RESULTS: The mean storage temperature of the vaccines at the states vaccines central cold chain facilities was -2.

4°C and before storage at study site, it was 5.8°C but at the study site it was -4.54°C. Mean ±Standard Error in the Mean (SEM) IgG titers for the measles vaccines sourced from "Open Market", Ebonyi, Enugu, Imo, Anambra and Abia States were 0.793±0.051, 1.621±0.

015, 1.621±0.015, 1.715±0.081, 1.793±0.051 and 1.

683±0.078 respectively while the mean ±Standard Error in the Mean (SEM) IgM titres were 0.857±0.037, 1.400±0.030, 1.391±0.

032, 1.339±0.037, 1.405±0.066 and 1.279±0.025 respectively.

One way analysis of variance shows that there is statistical difference in the IgG and IgM antibodies titers produced by the control compared to the vaccines (P value < 0.0001). Also, Bartlett's test for equal variances showed that there was statistical difference (P value < 0.0001 for IgG and = 0.036 for IgM). The antibodies elicited by the vaccines from the states were enough to confer protection but the vaccine samples from "Open Market" (control) could not evoke enough antibodies. CONCLUSION: The cold-chain technology in the region was judged to be optimal as at the time of vaccine sampling since all the measles vaccines had good immunogenicity profile.

However, efforts are still needed to maintain these facilities in good condition in order to ensure effective immunization program in the region.10.11604/pamj.supp.2017.27.3.

11491. eCollection 2017.Immune responses and characterization of antibody.to it were used to induce active and passive immunity to herpes virus-induced tumors in experimental animals. The results demonstrated the increased resistance of animals to transplantation of tumor cells due to vaccination with VIA-containing preparations. Thus, in Polysaccharides -vaccinated animals there was a delay in the development of tumors and the survival time was significantly higher than in the controls. The sera of these animals contained antibodies to VIA in high titres.

Experiments with passive immunization also gave encouraging results.various age groups and in healthy persons. It is established that the level of IgA (mostly sIgA)) in coprofiltrates of patients is considerably increased and that the local production of sIgA starts very short (in 2--3 days) after the beginning of the disease. Specific coproantibodies are chiefly sIgA-antibodies.