-Such-structural-motifs-are-important-precursors-for-further-transformations-into-biologically-active-compounds-and-useful-synthetic-intermediates-and-may-have-potential-applications-in-asymmetric-syntheses-as-olefin-ligands-or-organocatalysts-c

To further tackle this challenge, we accomplished the phosphoric acid-catalyzed enantioselective direct arylative reactions of 2-naphthol and 2-naphthamine with quinone derivatives to deliver efficient access to a class of axially chiral BINOL and NOBIN derivatives in good yields with excellent enantioselectivities under mild reaction conditions. Most importantly, we discovered that the azo group can effectively perform as a directing and activating group for organocatalytic formal aryl C-H functionalization via formal nucleophilic aromatic substitution of azobenzene derivatives. Thus, a wide range of axially chiral arylindoles were synthesized in good yields with excellent enantioselectivities. We anticipate that this strategy will foster the development of many other transformations and motivate a new enthusiasm for organocatalytic enantioselective aryl functionalization. Moreover, SPINOLs are fundamental synthetic precursors in the construction of other chiral organocatalysts and ligands. We have successfully developed a phosphoric acid-catalyzed enantioselective approach for SPINOLs.

This approach is highly convergent and functional-group-tolerant for the efficient generation of SPINOLs with good results, thus delivering practical access to this DHEA-S-loading test in cases of intrauterine growth retardation: relationship between the pattern of the maternal plasma metabolites and the fetoplacental Tanguy G, Thoumsin HJ, Zorn JR, Cedard L.Dehydroepiandrosterone sulfate loading tests (DLT) have been performed in 17 cases of clinically suspected intrauterine fetal growth retardation. At birth, 9 babies had adequate birth weights for gestational age (AGA) and 8 infants were small for gestational age (SGA). In both groups, plasma levels of dehydroepiandrosterone sulfate (DHEA-S), unconjugated DHEA, delta4-adrostenedione (delta4-A), testosterone (T), unconjugated estrone (E1) and estradiol (E2) were measured seven times from 15 min to 4 h after the intravenous injection of 50 mg DHEA-S. Several differences appear between the significantly increased and remain elevated for 2-3 h, whereas in the AGA group these values are increased only for a short period of time just after the injection. E1 and E2 patterns are similar in both groups. cyanocobalamin salcaprozate sodium has previously been demonstrated that an impaired response to DLT reflects a reduced uteroplacental blood flow.

In addition, our results suggests a concomitant impairment of the aromatizing activity which reduces the placental metabolization of neutral Cyclo[n]carbons and catenanes from different perspectives: disentangling the Sciences, Comenius University in Bratislava, Ilkovičova 6, 84215 Bratislava, All-carbon atomic rings, cyclo[n]carbons, have recently attracted vivid attention of experimentalists and theoreticians. Among them, cyclo[18]carbon is the most studied system. In this paper, we summarize and review various properties of cyclo[n]carbons, emphasising the aspects of their aromaticity/antiaromaticity. In the first part, the trends in bonding patterns and selected aromaticity indices with the increasing size of the rings are discussed. In the second part we explore the properties of catenane models based on interlocked cyclo[18]carbon rings from different perspectives and investigate their behaviour under the action of external force using computational Multi-decker tricarbonyl-bridged sandwich complexes of transition metals: structure, stability and electron-counting rules.Rostov-on-Don 344090, Russian Federation.Structures and stabilities of a new family of multi-decker tricarbonyl-bridged sandwich complexes of transition metals (Cr, Mn, Fe) have been studied using DFT B3LYP/6-311+G(df,p) calculations.

Stable structures satisfy the (12n + 6) electron-counting rule, where n is the number of metal atoms. Lengthening of the molecular chains is accompanied by growth of aromaticity of the inner basal cycles, lowering of the aromaticity of the terminal basal cycles and decrease in the energy gap between the frontier orbitals.A theoretical NMR study of ortho and para-substituted benzenes compared with silabenzenes, pyridines and phosphabenzenes.Calculations of absolute shieldings and nuclear-independent chemical shift phosphabenzenes) allowed to discuss the absolute shieldings in the function of Brown σ(p)(+) substituent constant and to predict 71 new chemical shifts. The silabenzenes that it is almost insensitive to substituent effects. In these set of compounds, it can be concluded that the aromaticity and its sensitivity to Synthesis of o-Carboxyarylacrylic Acids by Room Temperature Oxidative Cleavage of Hydroxynaphthalenes and Higher Aromatics with Oxone.A simple procedure for the synthesis of a variety of o-carboxyarylacrylic acids has been developed with Oxone (2KHSO5·KHSO4·K2SO4); the oxidation reaction involves the stirring of methoxy/hydroxy-substituted naphthalenes, phenanthrenes, anthracenes, etc.

with Oxone in an acetonitrile-water mixture (1:1, v/v) at rt.