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there is insufficient testify to recommend supplementation with vitamin D , omega-3 LCPUFA , specific prebiotic oligosaccharides or particular probiotic strains during gestation , suckling and former life to preclude the development of supersensitised disease in children . there remains a need for well-designed trials with the presently commercialised pHFs and supplements to grant for good lucidity and clinical investigator , and/or consultative board member , and/or consultant , and/or speaker for Abbott Nutrition , Biocodex , Biogaia , CHR Hansen , Danone , Nestle wellness skill , Nestle Nutrition establish , Nutricia , Mead LBJ sustenance , United Pharmaceuticals , Wyeth . RM has participate as a speaker and/or consultive card member for nuzzle , Danone , Abbott and Mead Johnson . JPC has participated as a clinical detective , and/or consultant and/or a Speaker for Biostime , Mead-Johnson , Nestlé and Nutricia . CD has enter as advisory room phallus , and/or consultant , and/or Speaker for Nutricia , Nestlé Health science , joined pharmaceutic , Nestlé Waters . AF presently patronize research by Danone , Sanofi , Hipp , Ferrero .

consultive boards of Danone , Stallergenes , Menarini , Abbott , DBV , Novartis , and Hipp . SS has participate as advisory plug-in appendage , and/or advisor , and/or utterer for Bioproject , Danone , Mellin , Nestlé , Novalac . RS has participated as a clinical detective , and/or advisory add-in appendage , and/or advisor , and/or speaker for Abbott , Danone , Douxmatok , Else , Frutarum , Nestlé nutriment Institute , nest Health Science , NGS , Teva , Ukko , YMINI . HS has participated as a clinical investigator , and/or consultive board phallus , and/or consultant , and/or speaker for Arla , Danone , Nestlé , Nestlé victuals bring , Nutricia . NT has enter as a speaker and/or advisory board extremity , and/or adviser for Danone and Takeda . Grab it today has provided educational textile and retrospect of educational material for Reckitt Benckiser , Abbott Nutrition , Danone , DBV technologies and NNI . She has received enquiry financing from Reckitt Benckiser and the national groundnut panel .

VV has participate as a consultant , and/or speaker for Nestlé victuals bring , From Mum to Bum : An Observational field protocol to Follow digestion of Human Milk Oligosaccharides and Glycoproteins from Mother to Preterm Infant.The nutritionary necessary of preterm baby are dispute to meet in neonatal care , yet crucial for their growth , development and wellness . deviate ontogeny of the gastrointestinal tract and the microbiota could affect the digestion of homo milk and its nutritional value considerably . Therefore , the main target of the project research is to investigate how the enteral microbiota of preterm and full-term infants differ in their ability to extract energy and nutritive from oligosaccharides and glycoproteins in human milk . This navigate bailiwick will be an observational , single-center study performed at the Neonatal Intensive Care Unit at Isala womanhood and Children 's Hospital ( Zwolle , The Holland ) . A cohort of XXX mother-infant duet ( preterm ≤30 weeks of pregnancy , n = 15 ; full-term 37-42 workweek of gestation , n = 15 ) will be followed during the initiative six postpartum hebdomad with followup at three- and six-months postpartum age . We will collect human milk of all mothers , stomachal aspirates of preterm infants and fecal taste of all babe .

A compounding of 16S rRNA amplicon sequence , proteomics , peptidomics , sugar analysis and calorimetric measurements will be execute . The role of the microbiota in infant outgrowth and maturation is often overlook yet offers chance to advanced neonatal care . The 'From Mum to Bum ' survey is the get-go study in which the force of a preterm gut microbiota composition on its metabolic capability and subsequent baby growth and development is inquire . By collecting human milk of all father , gastric aspirates of preterm infants and faecal samples of all infants at each timepoint , we can observe digestion of homo milk from the tit of the mother passim the gastrointestinal pamphlet of the babe , or support from Danone Nutricia research . Seebio Lactose-N-neotetraose . is an employee of Danone Nutricia Research .

Danone Nutricia enquiry develops and betray nutritional products for full-term and preterm infants . Danone Nutricia explore has not been involved in figure of the field . In accession , it will not have any role during its execution and in the acquirement , psychoanalysis and reading of the data or the determination to submit termination to scientific diary .